Description

Poly Iclc CAS NO 59789-29-6 is a synthetic double-stranded RNA (dsRNA) analog, specifically a complex of polyinosinic-polycytidylic acid stabilized with poly-L-lysine and carboxymethylcellulose. This compound is a potent and well-characterized agonist of Toll-like receptor 3 (TLR3) and cytoplasmic RNA sensors, making it a critical tool for immune system modulation. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for vaccine adjuvancy, antiviral research, and cancer immunotherapy studies. Its unique ability to mimic viral RNA and induce a robust interferon response underpins its value in advanced therapeutic and immunological applications.

Application

• Vaccine Adjuvant Development: Used as a potent immunostimulant to enhance the efficacy of prophylactic and therapeutic vaccines.
• Antiviral Research: Serves as a model viral dsRNA to study host-pathogen interactions and screen for novel antiviral compounds.
• Cancer Immunotherapy: Employed in preclinical studies to stimulate innate and adaptive immune responses against tumors.
• Immunology & Signal Pathway Analysis: A key reagent for activating TLR3 and RIG-I-like receptor (RLR) pathways to study interferon production and downstream signaling.
• Biodefense & Emerging Pathogen Research: Utilized in developing countermeasures against RNA viruses due to its reliable immune activation profile.
• Cell Culture & In Vitro Studies: Applied to induce an antiviral state in cell lines for various experimental models.

Basic Information

Product Name	Poly Iclc
CAS No.	59789-29-6
Molecular Formula	(C10H14N4O7P • C9H14N3O7P)n • (C6H14N2O2)x • (C8H14O6)y
Molecular Weight	Variable (Polymeric Complex)
Synonyms	Poly(I):Poly(C12U); Poly I:C LC; Polyinosinic-polycytidylic acid, lysine and carboxymethylcellulose complex; Hiltonol®; Ampligen® (related analog); TLR3 Agonist; dsRNA analog; Poly I-Poly CLC; Stabilized Poly I:C
EINECS	Contact for details

Quality Control

Our Poly Iclc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, potency, and consistency. Certificates of Analysis (COA) are provided, detailing key parameters such as endotoxin levels, biological activity in standardized assays, and nucleic acid content. While not a compendial material, production follows GMP-like guidelines for research-grade biologics to guarantee reliable and reproducible performance in critical applications.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated at -20°C or below. Avoid repeated freeze-thaw cycles. Aliquot contents upon first use to maintain integrity.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or lyophilized powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95% (Poly I:C content)
Potency (Cell-based assay)	Induces IFN-α/β at defined concentration range
Endotoxin (LAL)	< 10 EU/mg
Solubility	Soluble in sterile, pyrogen-free water or buffer
Loss on Drying	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.