Description

Desethylpiperacillin is a key intermediate and metabolite in the synthesis and pharmacokinetic study of the broad-spectrum antibiotic piperacillin. This compound is of significant value for pharmaceutical research and development, particularly in the investigation of antibiotic metabolism, efficacy, and the development of analytical reference standards. It is primarily utilized by research institutions, pharmaceutical manufacturers, and quality control laboratories engaged in advanced antibiotic development and regulatory compliance testing.

Application

• Pharmaceutical Intermediate: Critical building block in the synthetic pathway for piperacillin and related β-lactam antibiotics.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify piperacillin metabolites in biological matrices.
• Pharmacokinetic Research: Essential for studies investigating the absorption, distribution, metabolism, and excretion (ADME) profiles of piperacillin.
• Quality Control & Assurance: Serves as a high-purity reference material for HPLC, LC-MS, and other analytical methods to ensure the purity and consistency of active pharmaceutical ingredients (APIs).
• Impurity Profiling: Used to identify, characterize, and control process-related impurities in piperacillin API manufacturing.
• Stability Studies: Employed in forced degradation studies to understand the stability profile and degradation pathways of piperacillin.

Basic Information

Product Name	Desethylpiperacillin
CAS No.	59703-78-5
Molecular Formula	C22H26N5NaO6S
Molecular Weight	519.53 g/mol
Synonyms	Desethyl Piperacillin; Piperacillin Desethyl Metabolite; (2S,5R,6R)-6-[[(2R)-2-[[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; Sodium (2S,5R,6R)-6-[(R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Piperacillin Impurity D; Desethyl Piperacillin Sodium Salt
EINECS	Contact for details

Quality Control

Our Desethylpiperacillin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for research and reference applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	97.0% - 102.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.