Description

(10R)-10-Demethyl-21-Hydroxy-10-Methoxycarbonylprotostreptovaricin I is a structurally complex ansamycin antibiotic derivative, primarily valued for its role as a critical intermediate in advanced pharmaceutical research and development. Its significance lies in its utility for synthesizing novel therapeutic agents and for studying structure-activity relationships within the streptovaricin and ansamycin class of compounds. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on antibiotic discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel ansamycin-based antibiotics and other bioactive molecules.
• Antibiotic Research: Used as a reference standard and precursor in microbiological and pharmacological studies to investigate mechanisms of action against resistant bacterial strains.
• Structure-Activity Relationship (SAR) Studies: Critical for medicinal chemistry programs aiming to modify the protostreptovaricin core to enhance potency, reduce toxicity, or improve pharmacokinetic properties.
• Biochemical Research: Employed in enzymatic studies and as a tool compound to probe biological pathways affected by ansamycins.
• High-Purity Reference Standard: Supplied as a certified material for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	(10R)-10-Demethyl-21-Hydroxy-10-Methoxycarbonylprotostreptovaricin I
CAS No.	59556-95-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	10-Demethyl-21-hydroxy-10-methoxycarbonylprotostreptovaricin I; Protostreptovaricin I derivative; Ansamycin derivative; Streptovaricin derivative; (10R)-form; Antibiotic intermediate G2X; Research compound 59556-95-5
EINECS	Contact for details

Quality Control

Our (10R)-10-Demethyl-21-Hydroxy-10-Methoxycarbonylprotostreptovaricin I is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.