Description

Sodium [2S-[2Alpha,5Alpha,6Beta(S*)]]-6-[(Aminocyclohexa-1,4-Dien-1-Ylacetyl)Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate is a high-purity sodium salt derivative of a penicillanic acid sulfone, representing a key advanced intermediate in modern pharmaceutical synthesis. This compound is critical for the development of next-generation β-lactamase inhibitors, which are essential in combating antibiotic-resistant bacterial infections. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of novel antibacterial agents and combination therapies.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of potent β-lactamase inhibitors, such as tazobactam and related compounds.
• Antibiotic Research & Development: Used in medicinal chemistry for creating new antibiotic formulations to overcome multi-drug resistant bacteria.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the final chemical steps for manufacturing certain combination antibiotic drugs.
• Biochemical Research: Utilized in studies investigating enzyme inhibition mechanisms and structure-activity relationships (SAR) of β-lactam compounds.
• Process Chemistry: Applied in scaling up production processes for pharmaceutical actives under current Good Manufacturing Practices (cGMP).

Basic Information

Product Name	Sodium [2S-[2Alpha,5Alpha,6Beta(S*)]]-6-[(Aminocyclohexa-1,4-Dien-1-Ylacetyl)Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate
CAS No.	59446-81-0
Molecular Formula	C16H20N3NaO5S
Molecular Weight	389.40 g/mol
Synonyms	(2S,5R)-3,3-Dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt (related isomer); Sodium 6-(2-phenylacetamido)penicillanate derivative; Penicillanic acid sulfone sodium salt intermediate; Tazobactam precursor sodium salt; Sodium (2S,5R)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate analog; 6-APA sulfone sodium derivative; β-Lactamase inhibitor intermediate sodium salt.
EINECS	Contact for details

Quality Control

Our Sodium [2S-[2Alpha,5Alpha,6Beta(S*)]]-6-[(Aminocyclohexa-1,4-Dien-1-Ylacetyl)Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate is manufactured under strict quality systems. The product undergoes rigorous analytical testing to ensure it meets exacting standards for pharmaceutical intermediate applications. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and impurity profiles. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits
Heavy Metals	≤ 20 ppm
Microbial Limits	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.