Description

1,4-Dideoxy-30-Hydroxy-1,4-Dioxorifamycin is a semi-synthetic derivative of the rifamycin class of antibiotics, known for its potent biological activity. This compound is a key intermediate in the synthesis of advanced antimicrobial agents, offering significant value in pharmaceutical research and development. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of novel antibiotics targeting resistant bacterial strains. Its precise chemical structure allows for targeted modifications to enhance efficacy and pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of next-generation rifamycin-based antibiotics.
• Antimicrobial Research: Used in biochemical and microbiological research to study structure-activity relationships (SAR) and mechanisms of action against bacteria.
• API Development: Serves as a building block in the development of new Active Pharmaceutical Ingredients (APIs) for treating tuberculosis and other bacterial infections.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Preclinical Studies: Utilized in in-vitro and in-vivo studies to evaluate the efficacy and toxicity profiles of new antimicrobial candidates.

Basic Information

Product Name	1,4-Dideoxy-30-Hydroxy-1,4-Dioxorifamycin
CAS No.	59264-04-9
Molecular Formula	C38H47NO13
Molecular Weight	725.78 g/mol
Synonyms	1,4-Dideoxy-1,4-dioxorifamycin S; 30-Hydroxy-1,4-dideoxy-1,4-dioxorifamycin; Rifamycin S, 30-hydroxy-1,4-dideoxy-1,4-dioxo-; 30-Hydroxy-1,4-dioxo-1,4-dideoxyrifamycin S; 1,4-Dideoxy-30-hydroxy-1,4-dioxorifamycin S; Antibiotic X 149; A 272
EINECS	Contact for details

Quality Control

Our 1,4-Dideoxy-30-Hydroxy-1,4-Dioxorifamycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Reddish-brown to orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.