Description

Guanosine 5'-Diphosphate-3'-Monophosphate is a high-purity nucleotide derivative essential for advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and research tool for studying nucleotide metabolism, enzyme kinetics, and signal transduction pathways. It is primarily utilized by research institutions, diagnostic manufacturers, and biotechnology companies engaged in enzymology, molecular biology, and the development of novel therapeutic agents.

Application

• Biochemical Research: As a substrate or cofactor in enzymatic assays to study kinases, phosphatases, and other nucleotide-metabolizing enzymes.
• Diagnostic Reagent Manufacturing: A key component in the formulation of high-sensitivity diagnostic kits for metabolic and genetic disorders.
• Pharmaceutical Development: Used in the research and development of nucleotide-based therapeutics, including antiviral and anticancer drugs.
• Enzymology Studies: Critical for investigating the mechanisms and kinetics of enzymes involved in purine and pyrimidine metabolism.
• Cell Signaling Research: Employed in studies of intracellular signaling cascades where nucleotide derivatives act as second messengers.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in laboratories.

Basic Information

Product Name	Guanosine 5'-Diphosphate-3'-Monophosphate
CAS No.	58902-76-4
Molecular Formula	C10H16N5O14P3
Molecular Weight	523.17 g/mol
Synonyms	Guanosine 5'-diphosphate 3'-monophosphate; 3'-GMP-5'-GDP; Guanosine 5'-diphosphate-3'-(dihydrogen phosphate); pppGp; 5'-GDP-3'-GMP; Guanosine-5'-diphosphate-3'-monophosphoric acid; GDP-3'-monophosphate
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Diphosphate-3'-Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and bioburden, ensuring compliance with research-grade and potential cGMP guidelines for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, temperature-controlled environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	2.0 - 4.0
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.