Description

2-Amino-5-Chloro-3-(Trifluoromethyl)Benzoic Acid is a high-value trifluoromethylated benzoic acid derivative, serving as a critical pharmaceutical intermediate and building block in advanced organic synthesis. Its unique structure, combining an amino group, a chloro substituent, and a trifluoromethyl group on the aromatic ring, makes it indispensable for constructing complex molecules with enhanced biological activity and metabolic stability. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in medicinal chemistry and organic synthesis, enabling the introduction of multiple functional groups.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments requiring halogenated and fluorinated aromatic components.

Basic Information

Product Name	2-Amino-5-Chloro-3-(Trifluoromethyl)Benzoic Acid
CAS No.	58026-23-6
Molecular Formula	C8H5ClF3NO2
Molecular Weight	239.58 g/mol
Synonyms	5-Chloro-2-amino-3-(trifluoromethyl)benzoic acid; Benzoic acid, 2-amino-5-chloro-3-(trifluoromethyl)-; 2-Amino-5-chloro-alpha,alpha,α-trifluoro-m-toluic acid; 3-Trifluoromethyl-2-amino-5-chlorobenzoic acid; 58026-23-6; 2-Amino-5-chloro-3-trifluoromethylbenzoic acid; 5-Chloro-2-amino-alpha,alpha,α-trifluoro-m-toluic acid
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our products undergo comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to verify identity and purity against established specifications. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request. Our commitment to quality supports compliance with cGMP and ISO standards where applicable for intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.