Description

Methyl 5-Bromo-2-Fluorobenzoate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and functional agrochemicals, where the introduction of halogen and fluorine substituents is critical for modulating biological activity and material properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the fluorine atom enhances bioavailability and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in display technologies.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport materials and emissive layer components.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing complex aromatic systems in academic and industrial R&D labs.

Basic Information

Product Name	Methyl 5-Bromo-2-Fluorobenzoate
CAS No.	57381-59-6
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	5-Bromo-2-fluorobenzoic acid methyl ester; Methyl 5-bromo-2-fluorobenzoate; 2-Fluoro-5-bromobenzoic acid methyl ester; Benzoic acid, 5-bromo-2-fluoro-, methyl ester; Methyl 2-fluoro-5-bromobenzoate; 5-Bromo-2-fluorobenzoic Acid Methyl Ester; Methyl 5-Bromo-2-Fluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-2-Fluorobenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We are committed to meeting the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.