Description

3-Bromorifamycin S is a chemically modified derivative of the potent ansamycin antibiotic rifamycin S, where a bromine atom is introduced at the 3-position of the naphthoquinone core. This structural modification is crucial for medicinal chemistry research, particularly in the development of novel antibacterial agents and the study of structure-activity relationships (SAR). It serves as a key synthetic intermediate for pharmaceutical R&D laboratories and fine chemical manufacturers focused on antibiotic innovation. The compound is essential for researchers targeting bacterial RNA polymerase and developing next-generation treatments against resistant strains.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel rifamycin analogs and semi-synthetic antibiotics.
• Medicinal Chemistry Research: Used in Structure-Activity Relationship (SAR) studies to optimize antibacterial potency and pharmacokinetic properties.
• Biochemical Research: Serves as a tool compound for studying the inhibition mechanism of bacterial DNA-dependent RNA polymerase.
• Antibiotic Development: A precursor in R&D programs aimed at overcoming bacterial resistance to existing rifamycin-class drugs.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for advanced pharmaceutical projects.
• Reference Standard: Used as an analytical standard in quality control laboratories for antibiotic manufacturing.

Basic Information

Product Name	3-Bromorifamycin S
CAS No.	57375-25-4
Molecular Formula	C37H46BrNO12
Molecular Weight	784.67 g/mol
Synonyms	3-Bromo-rifamycin S; Rifamycin S, 3-bromo-; 3-Bromo-rifampicin S; 3-Bromorifampicin S; 3-Br-Rif S; (12Z,14E,24E)-(2S,16S,17S,18R,19R,20R,21S,22R,23S)-21-Acetyloxy-6,9,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-3-bromo-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-5-yl acetate; 3-Bromoansamycin S
EINECS	Contact for details

Quality Control

Our 3-Bromorifamycin S is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Our quality commitment supports reliable and reproducible results in your critical development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage, consider holding under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Reddish-brown to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.