Description

2-Hydroxy-3-Methoxy-6 β-Naltrexol is a key pharmaceutical intermediate and reference standard of significant importance in research and development. This compound is primarily valued for its role in the synthesis and analytical characterization of opioid receptor antagonists and related active pharmaceutical ingredients (APIs). It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on neuropharmacology, drug metabolism studies, and the development of new therapeutic agents targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced opioid antagonists and related therapeutic compounds.
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) testing in HPLC, LC-MS, and other chromatographic systems.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism of naltrexone and similar drugs.
• Biochemical Research: A tool compound for investigating opioid receptor binding, signal transduction pathways, and neurochemical mechanisms.
• Impurity Standard: Serves as a certified reference material for identifying and quantifying related substances in API batches.
• Preclinical & Clinical Research: Supports drug discovery and development programs targeting addiction medicine and pain management.

Basic Information

Product Name	2-Hydroxy-3-Methoxy-6 β-Naltrexol
CAS No.	57355-35-8
Molecular Formula	C21H27NO5
Molecular Weight	373.45 g/mol
Synonyms	6β-Naltrexol; 6β-Naltrexol metabolite; 6β-Hydroxy-naltrexone; 2-Hydroxy-3-methoxy-17-(cyclopropylmethyl)-4,5α-epoxymorphinan-6β-ol; Noroxymorphone derivative; 6β-OH-Naltrexone; 17-(Cyclopropylmethyl)-4,5α-epoxy-2-hydroxy-3-methoxy-6β-morphinan-6-ol
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-3-Methoxy-6 β-Naltrexol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis to ensure compliance with high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.