Description

Sinemet CAS NO 57308-51-7 is a critical pharmaceutical active ingredient, specifically a combination of carbidopa and levodopa. This compound is essential for the effective management of Parkinson's disease symptoms, primarily by increasing dopamine levels in the brain. It is a fundamental component for pharmaceutical manufacturers producing medications aimed at improving motor control and quality of life for patients.

Application

• Pharmaceutical Formulations: Primary active ingredient in tablets and capsules for the treatment of Parkinson's disease and parkinsonism.
• Neurological Disorder Management: Used in medications designed to control tremors, stiffness, and slowness of movement associated with Parkinson's.
• Controlled-Release Drug Development: Incorporated into advanced drug delivery systems for sustained therapeutic effect.
• Generic Drug Manufacturing: Serves as the key API for producing bioequivalent generic versions of branded Parkinson's medications.
• Clinical Research: Utilized as a reference standard in pharmacological studies and clinical trials for neurodegenerative diseases.
• Hospital Pharmacy Compounding: May be used in specialized compounding for tailored patient dosage regimens.

Basic Information

Product Name	Sinemet
CAS No.	57308-51-7
Molecular Formula	C10H14N2O4 • C9H11NO4
Molecular Weight	226.23 (Carbidopa) + 197.19 (Levodopa)
Synonyms	Carbidopa/Levodopa; Lodosyn; Levodopa/Carbidopa; MK-486/L-Dopa; (S)-3-(3,4-Dihydroxybenzyl)-2-hydrazino-2-methylpropanoic acid / (S)-2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid; Atamet; Co-careldopa; Duodopa (for intestinal gel); Pharmacological combination for Parkinson's
EINECS	Contact for details

Quality Control

Our Sinemet is manufactured under strict quality systems to meet the rigorous standards required for pharmaceutical active ingredients. Quality is assured through comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, IR spectroscopy, and titration methods. We provide full traceability and Certificates of Analysis (COA) for each batch, ensuring compliance with relevant pharmacopoeial guidelines (e.g., USP, EP) and cGMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, the container must be kept tightly sealed after each use to minimize exposure to moisture and air. For long-term storage, consider using desiccants and maintaining an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (combined for Carbidopa and Levodopa)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.