Description

N,S-Bis(Trifluoroacetyl)-L-Cysteine Trimethylsilyl Ester is a highly specialized, protected derivative of the amino acid L-cysteine, designed for advanced synthetic and analytical workflows. This compound is critical for researchers and manufacturers requiring precise, stable, and volatile derivatives for sensitive applications like gas chromatography (GC) and mass spectrometry (MS). It is primarily utilized in pharmaceutical research, proteomics, and analytical chemistry laboratories for amino acid analysis, peptide synthesis, and metabolic studies.

Application

• Amino Acid Derivatization for GC/MS Analysis: Serves as a key reagent to create volatile, thermally stable derivatives of cysteine and other amino acids for accurate quantification and identification in complex biological matrices.
• Pharmaceutical Intermediate: Used in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs) where the protection of the thiol and amino groups is required.
• Proteomics and Metabolomics Research: Essential for labeling and analyzing protein and metabolic samples, enabling the study of protein structure, function, and post-translational modifications.
• Biochemical Research Reagent: Employed in studies involving sulfur-containing amino acids, enzyme mechanisms, and redox biology.
• Quality Control and Reference Standard: Acts as a high-purity reference material for calibrating analytical instruments and validating methods in quality control laboratories.

Basic Information

Product Name	N,S-Bis(Trifluoroacetyl)-L-Cysteine Trimethylsilyl Ester
CAS No.	57207-35-9
Molecular Formula	C12H16F6NO3SSi
Molecular Weight	396.31 g/mol
Synonyms	L-Cysteine, N,S-bis(trifluoroacetyl)-, trimethylsilyl ester; N,S-Bis(trifluoroacetyl)-L-cysteine TMS ester; N,S-Bis(trifluoroacetyl)cysteine trimethylsilyl ester; (2R)-2-[(Trifluoroacetyl)amino]-3-{[trimethylsilyl)oxy]sulfanyl}-3-oxopropyl trifluoroacetate; BTF-Cys-OTMS; TFA-Cys(TFA)-OTMS; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our N,S-Bis(Trifluoroacetyl)-L-Cysteine Trimethylsilyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and analytical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific customer requirements for advanced research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the product label or COA. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere (e.g., nitrogen) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.