Description

Metolazone CAS NO 56436-32-9 is a high-purity pharmaceutical active ingredient belonging to the quinazoline class of diuretics. It is a critical component in the formulation of antihypertensive and diuretic medications, valued for its efficacy in managing edema and hypertension. This compound is essential for pharmaceutical manufacturers, research institutions, and chemical suppliers serving the global healthcare sector.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the manufacture of prescription diuretic and antihypertensive medications.
• Pharmaceutical Research & Development: Serves as a key reference standard and intermediate in developing new therapeutic formulations and conducting bioequivalence studies.
• Generic Drug Manufacturing: A vital raw material for producing cost-effective generic versions of branded metolazone-based drugs.
• Clinical Trial Material: Supplied under strict quality protocols for use in Phase I-IV clinical trials investigating cardiovascular treatments.
• Chemical Synthesis Intermediate: Used in specialized organic synthesis for creating novel quinazoline derivatives.

Basic Information

Product Name	Metolazone
CAS No.	56436-32-9
Molecular Formula	C16H16ClN3O3S
Molecular Weight	365.83 g/mol
Synonyms	7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide; Zaroxolyn; Mykrox; Diulo; Metolazon; 2-Methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydro-6-sulfamoylquinazoline-7-carboxylic acid amide
EINECS	Contact for details

Quality Control

Our Metolazone is manufactured under cGMP (current Good Manufacturing Practice) conditions, ensuring the highest standards of purity and consistency for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC assay, related substances analysis, residual solvent screening, and identity confirmation (IR, NMR). We provide full traceability and Certificates of Analysis (COA) that comply with major pharmacopeial standards (USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.