Description

Metolazone is a quinazoline-derived diuretic and antihypertensive agent, widely recognized for its efficacy in managing fluid retention and high blood pressure. Its primary value lies in its unique mechanism of action, which allows for effective treatment even in patients with reduced kidney function. This active pharmaceutical ingredient (API) is essential for manufacturers in the global pharmaceutical industry developing formulations for cardiovascular and renal conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of prescription diuretic and antihypertensive medications.
• Hypertension Treatment: Formulated into tablets or capsules for the management of essential hypertension.
• Edema Management: Used in drugs to treat edema associated with congestive heart failure (CHF) and renal disease, including nephrotic syndrome.
• Clinical Research: Serves as a reference standard or building block in pharmacological R&D for novel cardiovascular therapies.
• Generic Drug Production: A key component for pharmaceutical companies producing bioequivalent generic versions of branded metolazone drugs.

Basic Information

Product Name	Metolazone
CAS No.	56436-31-8
Molecular Formula	C16H16ClN3O3S
Molecular Weight	365.83 g/mol
Synonyms	7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide; Zaroxolyn; Mykrox; Diulo; Metolazon; 3-(2-Methylphenyl)-2-methyl-4-oxo-6-sulfamoyl-1,2,3,4-tetrahydroquinazoline-7-chloride
EINECS	Contact for details

Quality Control

Our Metolazone is manufactured under strict quality management systems, targeting standards suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing including identification, purity assay, and impurity profiling to ensure it meets stringent specifications. A Certificate of Analysis (COA) documenting results for identity, potency, and related substances is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.