Description

n-Acetyl-L-Glutamic Acid Bis(Trimethylsilyl) Derivative is a key silylated derivative of N-acetyl-L-glutamic acid, primarily used as a protected intermediate in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise control over reactivity and stability during complex chemical transformations. It is particularly valuable in the synthesis of peptides, modified amino acids, and other fine chemicals within the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected glutamic acid derivative to prevent unwanted side reactions during solid-phase and solution-phase peptide coupling.
• Bioconjugation & Labeling: Facilitates the introduction of functional groups or labels onto biomolecules for research and diagnostic applications.
• Analytical Chemistry: Serves as a derivatization agent for gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analysis of amino acids and related compounds.
• Biochemical Research: Employed in metabolic studies and enzymatic research involving glutamic acid pathways.
• Fine Chemical Synthesis: A versatile intermediate for creating specialty chemicals with tailored properties for various industrial applications.

Basic Information

Product Name	n-Acetyl-L-Glutamic Acid Bis(Trimethylsilyl) Deriv.
CAS No.	56272-70-9
Molecular Formula	C15H31NO4Si2
Molecular Weight	345.59 g/mol
Synonyms	N-Acetyl-L-glutamic acid bis(trimethylsilyl) ester; L-Glutamic acid, N-acetyl-, bis(trimethylsilyl) ester; N-Acetylglutamic acid bis-TMS ester; (2S)-2-Acetamidopentanedioic acid bis(trimethylsilyl) ester; Ac-Glu-O-TMS; N-Ac-Glu(OTMS)2; N-Acetyl-L-glutamic acid di(trimethylsilyl) derivative
EINECS	Contact for details

Quality Control

Our n-Acetyl-L-Glutamic Acid Bis(Trimethylsilyl) Derivative is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. Handle and store away from strong bases and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.