Description

3,3,3-Trifluoro-2-Hydroxy-2-Phenylpropanoic Acid is a high-value fluorinated organic building block characterized by its trifluoromethyl and α-hydroxy acid functionalities. This compound is essential for introducing the metabolically stable trifluoromethyl group into target molecules, significantly enhancing their lipophilicity and biological activity. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drug candidates, including protease inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in creating advanced herbicides and pesticides where the CF3 group improves compound stability and efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing their dielectric and optical properties.
• Advanced Material Science: Employed in the research and production of specialty polymers and coatings with unique surface characteristics.
• Organic Synthesis & Catalysis: Acts as a versatile reagent in asymmetric synthesis and as a ligand precursor in transition metal catalysis.
• Academic & Industrial R&D: A valuable compound for methodological development and exploring new fluorination chemistry in laboratory settings.

Basic Information

Product Name	3,3,3-Trifluoro-2-Hydroxy-2-Phenylpropanoic Acid
CAS No.	55519-22-7
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	2-Hydroxy-2-phenyl-3,3,3-trifluoropropanoic acid; α-Hydroxy-α-phenyl-β,β,β-trifluoropropionic acid; 3,3,3-Trifluoro-2-hydroxy-2-phenylpropionic acid; (RS)-3,3,3-Trifluoro-2-hydroxy-2-phenylpropanoic acid; (±)-3,3,3-Trifluoro-2-hydroxy-2-phenylpropanoic acid; TFHPA; Phenyltrifluorolactic acid
EINECS	Contact for details

Quality Control

Our production of 3,3,3-Trifluoro-2-Hydroxy-2-Phenylpropanoic Acid adheres to stringent in-process controls and final batch testing to ensure consistent high purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, chiral purity (if applicable), and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for research and commercial scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Chiral Purity (if applicable)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.