Description

6β-Naltrexol Hydrochloride is a high-purity pharmaceutical reference standard and active pharmaceutical ingredient (API) intermediate. This compound is critical for research, development, and quality control processes within the pharmaceutical industry, particularly in the study of opioid receptor antagonists. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development of addiction treatment therapies and related neuropharmacological research.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification, assay, and impurity profiling of naltrexone and related compounds in HPLC, LC-MS, and other analytical methods.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the manufacturing process of opioid antagonist medications.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research as a major metabolite of naltrexone for in vitro and in vivo studies.
• Biochemical Research: Used in receptor binding assays and other experimental protocols to study the mechanism of action at opioid receptors.
• Quality Control & Assurance: Essential for ensuring the purity, potency, and consistency of final drug products in GMP manufacturing environments.
• Method Development and Validation: A critical component for developing and validating new analytical methods in regulatory submissions.

Basic Information

Product Name	6β-Naltrexol Hydrochloride
CAS No.	55488-86-3
Molecular Formula	C20H24ClNO4
Molecular Weight	377.86 g/mol
Synonyms	6β-Naltrexol HCl; 6β-Naltrexol hydrochloride; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6β-ol hydrochloride; 6β-Hydroxynaltrexone hydrochloride; Noroxymorphone-6β-ol cyclopropylmethyl ether hydrochloride
EINECS	Contact for details

Quality Control

Our 6β-Naltrexol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) with full traceability are provided for every lot, supporting regulatory compliance in GMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.