Description

Polyguanylic Acid (5') Potassium Salt is a high-purity, synthetic polynucleotide composed of guanosine monophosphate units linked by 5'-5' phosphodiester bonds. This compound is a critical reagent in molecular biology and biochemistry research, serving as a model for RNA structure and function studies. It is essential for researchers and manufacturers in the fields of oligonucleotide synthesis, vaccine development, and diagnostic assay formulation who require consistent, high-quality nucleic acid components.

Application

• Molecular Biology Research: Used as a homopolymer template or primer in enzymatic reactions, including studies with reverse transcriptase and RNA-dependent RNA polymerases.
• Biochemical Assays: Serves as a standard or substrate in assays measuring nuclease activity, helicase function, or nucleic acid-protein interactions.
• Oligonucleotide Synthesis & Development: Acts as a reference compound or starting material for the development and quality control of synthetic oligonucleotides and analogs.
• Vaccine & Therapeutic Research: Investigated for its immunostimulatory properties as a potential adjuvant or component in mRNA vaccine and therapeutic platforms.
• Diagnostic Development: Utilized in the design and calibration of diagnostic tests that rely on nucleic acid hybridization, such as PCR and microarray technologies.
• Academic & Pharmaceutical R&D: A fundamental tool for studying RNA secondary structures like G-quadruplexes and their biological roles in telomere maintenance and gene regulation.

Basic Information

Product Name	Polyguanylic Acid (5') Potassium Salt
CAS No.	54684-83-2
Molecular Formula	(C10H12KN5O8P)n
Molecular Weight	Contact for details
Synonyms	Poly(G) Potassium Salt; 5'-Polyguanylic Acid Potassium Salt; Polyguanylate Potassium Salt; Poly(G) K⁺ Salt; Potassium Polyguanylate; Poly(5'-guanylic acid) potassium; Guanylic Acid Homopolymer Potassium Salt; Polyriboguanylic Acid Potassium Salt
EINECS	Contact for details

Quality Control

Our Polyguanylic Acid (5') Potassium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for life science research. Certificates of Analysis (COA) detailing specifications such as assay, chain length distribution, and endotoxin levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (UV, HPLC)	Complies
Assay (HPLC)	≥ 95% (Poly(G) content)
pH (Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg
Protein Content	< 0.1%
Solubility	Soluble in water, slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.