Description

n-Chloromethyl-4-Nitrophthalimide [For HPLC Labeling] is a specialized, high-purity chemical derivative designed for analytical chemistry applications. This compound matters as a critical derivatization reagent, enabling the sensitive detection and quantification of target analytes in complex matrices via High-Performance Liquid Chromatography (HPLC). It is primarily needed by analytical laboratories, pharmaceutical R&D departments, and chemical manufacturers engaged in method development, quality control, and trace analysis.

Application

• HPLC Derivatization Reagent: Used to tag amines, alcohols, or other nucleophiles to enhance their UV/Vis or fluorescence detection.
• Analytical Method Development: A key tool for creating sensitive and selective HPLC assays for pharmaceutical impurities, metabolites, or biomarkers.
• Chemical Synthesis Intermediate: Serves as a building block for synthesizing more complex phthalimide-based compounds or fluorescent probes.
• Quality Control (QC) Testing: Employed in pharmaceutical and chemical industry QC labs for precise impurity profiling and content uniformity testing.
• Research & Development: Facilitates academic and industrial research in analytical chemistry, medicinal chemistry, and bio-conjugation techniques.
• Standards Preparation: Used in the preparation of certified reference materials (CRMs) and calibration standards for analytical instruments.

Basic Information

Product Name	n-Chloromethyl-4-Nitrophthalimide [For HPLC Labeling]
CAS No.	54455-37-7
Molecular Formula	C9H5ClN2O4
Molecular Weight	240.60 g/mol
Synonyms	4-Nitro-N-(chloromethyl)phthalimide; 1-(Chloromethyl)-4-nitrophthalimide; 4-Nitro-1-(chloromethyl)phthalimide; N-(Chloromethyl)-4-nitrophthalimide; Chloromethyl 4-nitrophthalimide; HPLC Labeling Reagent; Derivatization Agent; Phthalimide, N-(chloromethyl)-4-nitro-
EINECS	Contact for details

Quality Control

Our n-Chloromethyl-4-Nitrophthalimide [For HPLC Labeling] is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive analytical applications. Each lot undergoes comprehensive testing, including identity confirmation, purity assay, and impurity profiling via HPLC. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.