Description

3-Chloro-5-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic carboxylic acid derivative, distinguished by its trifluoromethyl and chloro substituents. This compound is a critical advanced pharmaceutical intermediate and a versatile building block for synthesizing complex molecules with enhanced biological activity and physicochemical properties. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Serves as a core building block for novel herbicides, fungicides, and insecticides, leveraging the stability imparted by the trifluoromethyl group.
• Liquid Crystal & OLED Materials: Used in the synthesis of advanced electronic materials for displays and lighting due to its aromatic structure and halogenated motifs.
• Polymer Modification: Acts as a monomer or modifier to introduce specific functional groups into polymer chains, enhancing material properties.
• Organic Synthesis & Research: A versatile reagent in academic and industrial research laboratories for constructing complex aromatic systems and exploring new chemical reactions.
• Coordination Chemistry: Functions as a ligand precursor for metal-organic frameworks (MOFs) and catalysts.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Benzoic Acid
CAS No.	53985-49-2
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	3-Chloro-5-(trifluoromethyl)benzoic acid; 5-Trifluoromethyl-3-chlorobenzoic acid; Benzoic acid, 3-chloro-5-(trifluoromethyl)-; 3-Chloro-alpha,alpha,α-trifluoro-m-toluic acid; m-Chloro-alpha,alpha,α-trifluorotoluic acid; 53985-49-2; 3-Chloro-5-trifluoromethylbenzoic acid
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-5-(Trifluoromethyl)Benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical specifications. Our quality system is designed to support cGMP requirements for pharmaceutical intermediates and meet the exacting standards of global industrial customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.