Description

Rifamycin W is a key intermediate in the synthesis of clinically significant rifamycin antibiotics. This compound is essential for pharmaceutical manufacturers and research institutions developing next-generation antimicrobial agents to combat resistant bacterial strains. Its primary value lies in enabling the production of potent, semi-synthetic rifamycins used in treating tuberculosis, leprosy, and other serious infections. Industries requiring this high-purity intermediate include pharmaceutical API synthesis, advanced biomedical research, and fine chemical production.

Application

• Pharmaceutical Intermediate: Critical precursor in the chemical synthesis of semi-synthetic rifamycin antibiotics like Rifampicin, Rifabutin, and Rifapentine.
• Antimicrobial Research: Used as a reference standard and building block in R&D for novel antibiotics targeting RNA polymerase in bacteria.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a key starting material (KSM) or advanced intermediate in GMP-compliant production lines for anti-tuberculosis drugs.
• Biochemical Studies: Employed in mechanistic studies to understand the structure-activity relationship (SAR) of the rifamycin class.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for specialized, high-value chemical entities.

Basic Information

Product Name	Rifamycin W
CAS No.	53904-81-7
Molecular Formula	C37H47NO12
Molecular Weight	697.77 g/mol
Synonyms	Rifamycin W; Rifamycin S Precursor; 25-Deacetylrifamycin S; Rifamycin SV Intermediate; Antibiotic AF/ABD 308; NSC 133100; (12Z,14E,24E)-(2S,12S,13S,14R,15S,16S,17R,18R,19S,20S,21S,22R,23S)-21-Acetyloxy-6,9,13,15,17,19,23-heptahydroxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-5-yl acetate
EINECS	Contact for details

Quality Control

Our Rifamycin W is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through comprehensive analytical testing, including HPLC for assay and related substances, IR for identification, and stringent control of residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.