Description

2,3,4,5,6-Pentafluorobenzyl Chloroformate is a highly reactive and versatile derivatization reagent, primarily used to introduce the pentafluorobenzyl (PFB) protecting group. Its core value proposition lies in enabling the sensitive detection and analysis of target analytes, particularly in complex matrices, by forming stable, volatile derivatives suitable for gas chromatography. This compound is essential for researchers and quality control laboratories in the pharmaceutical, environmental, and agrochemical industries who require advanced analytical methodologies. Its specific reactivity makes it a critical tool for enhancing the chromatographic properties and detector response of carboxylic acids, amines, and phenols.

Application

• Analytical Chemistry Derivatization: A key reagent for preparing volatile, electron-capturing derivatives of polar compounds (e.g., carboxylic acids, amino acids) for enhanced analysis by Gas Chromatography (GC) with Electron Capture Detection (ECD) or Mass Spectrometry (GC-MS).
• Pharmaceutical Impurity Profiling & Metabolite Analysis: Used to derivative and detect trace-level drug metabolites, degradation products, and endogenous compounds in biological samples for pharmacokinetic and bioanalytical studies.
• Environmental Monitoring: Employed in the derivatization and sensitive detection of environmental pollutants, such as pesticide residues, phenols, and acidic herbicides, in water, soil, and food samples.
• Proteomics & Biochemical Research: Serves as a reagent for modifying peptides, amino acids, and other biomolecules to alter their solubility, stability, or detection characteristics during analysis.
• Chemical Synthesis Intermediate: Acts as a building block in organic synthesis for introducing the pentafluorobenzyloxycarbonyl (PFBOC) protecting group onto amines or for constructing more complex fluorinated molecules.
• Forensic Toxicology: Utilized in the preparation of samples for the confirmatory analysis of drugs of abuse and their metabolites due to the high sensitivity offered by PFB derivatives.

Basic Information

Product Name	2,3,4,5,6-Pentafluorobenzyl Chloroformate
CAS No.	53526-74-2
Molecular Formula	C8H2ClF5O2
Molecular Weight	260.55 g/mol
Synonyms	Pentafluorobenzyl Chloroformate; PFB-Chloroformate; Chloroformic Acid Pentafluorobenzyl Ester; 2,3,4,5,6-Pentafluorobenzyloxycarbonyl Chloride; PFBOC-Cl; Benzyl Chloroformate, 2,3,4,5,6-Pentafluoro-; Pentafluorobenzyloxycarbonyl Chloride
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorobenzyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity assay and identity confirmation (IR, NMR), to ensure it meets the high standards required for sensitive analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support compliance with various pharmacopeial and research-grade specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity with strong acids and bases, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.