Description

Methyl 2,3,4,6-Tetrafluorobenzoate is a high-purity fluorinated aromatic ester, a key building block in advanced organic synthesis. This compound is valued for its role in introducing the tetrafluorobenzoate moiety, which can impart desirable properties like enhanced metabolic stability and lipophilicity to target molecules. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals and organic semiconductors for display technologies and electronic devices.
• Advanced Polymer Modification: Employed to introduce fluorinated aromatic groups into polymer backbones, improving chemical resistance, thermal stability, and surface properties.
• Complex Ligand & Catalyst Development: Utilized in organometallic chemistry to create specialized ligands for catalysis, leveraging the electron-withdrawing effect of the fluorine substituents.
• Custom Fluorination Chemistry: Acts as a standardized starting material for contract research organizations (CROs) and custom synthesis facilities performing tailored fluorination reactions.

Basic Information

Product Name	Methyl 2,3,4,6-Tetrafluorobenzoate
CAS No.	53001-68-6
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	2,3,4,6-Tetrafluorobenzoic Acid Methyl Ester; Methyl 2,3,4,6-Tetrafluorobenzoate; Benzoic acid, 2,3,4,6-tetrafluoro-, methyl ester; Methyl Perfluorobenzoate (incorrect but common); Methyl Tetrafluorobenzoate; Metyl ester kyseliny 2,3,4,6-tetrafluorbenzoové; MFCD00042319
EINECS	Contact for details

Quality Control

Every batch of Methyl 2,3,4,6-Tetrafluorobenzoate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.