Description

3-[(5,6-Dibromohexyl)Oxyiminomethyl]Rifamycin CAS NO 52454-12-3 is a chemically modified derivative of the potent ansamycin antibiotic, rifamycin SV. This semi-synthetic compound is engineered to enhance specific pharmacological properties, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on developing novel antibacterial agents and exploring new therapeutic mechanisms.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation rifamycin-based antibiotics.
• Antibacterial Research: Used in biochemical and microbiological studies to investigate structure-activity relationships (SAR) against resistant bacterial strains.
• Mechanism of Action Studies: Employed in research to understand and inhibit bacterial RNA polymerase with modified specificity.
• Preclinical Development: Acts as a precursor molecule in the development of new drug candidates targeting tuberculosis and other Gram-positive infections.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-[(5,6-Dibromohexyl)Oxyiminomethyl]Rifamycin
CAS No.	52454-12-3
Molecular Formula	C43H56Br2N2O12
Molecular Weight	952.74 g/mol
Synonyms	3-[(5,6-Dibromohexyl)oxyiminomethyl]rifamycin; Rifamycin derivative, 3-[(5,6-dibromohexyl)oxyiminomethyl]-; 3-Formylrifamycin SV O-(5,6-dibromohexyl)oxime; (5,6-Dibromohexyl)oximinomethylrifamycin; Rifamycin SV 3-[(5,6-dibromohexyl)oxyiminomethyl] derivative
EINECS	Contact for details

Quality Control

Our 3-[(5,6-Dibromohexyl)Oxyiminomethyl]Rifamycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.