Description

Edeine A is a naturally occurring cyclic peptide antibiotic isolated from *Bacillus brevis*, recognized for its potent activity against Gram-positive bacteria and select Gram-negative strains. It functions by inhibiting protein synthesis through binding to the 50S ribosomal subunit, making it a valuable tool in antimicrobial research and development. This compound is primarily utilized by pharmaceutical R&D laboratories, academic institutions, and biotechnology companies engaged in antibiotic mechanism studies, resistance profiling, and novel therapeutic discovery. Edeine A CAS NO 52452-77-4 is supplied as a high-purity reference standard for analytical and experimental applications.

Application

• Antibiotic mode-of-action studies targeting bacterial ribosome function
• Reference standard for HPLC and LC-MS method development and validation
• In vitro antimicrobial susceptibility testing (AST) panels for Gram-positive pathogens
• Investigation of bacterial resistance mechanisms, including ribosomal mutation analysis
• Supporting preclinical pharmacology and toxicology studies requiring well-characterized antibiotics
• Quality control benchmark for biosynthetic or semi-synthetic analogues of edeine-class peptides
• Teaching and training materials in advanced microbiology and medicinal chemistry curricula
• Stability and degradation pathway studies under controlled environmental conditions

Basic Information

Product Name	Edeine A
CAS No.	52452-77-4
Molecular Formula	C62H103N17O16
Molecular Weight	1322.58 g/mol
Synonyms	Edeine A; Edeine-A; Edeine I; Edeine I-A; Antibiotic Edeine A; Bacitracin-related peptide (historical misattribution); Cyclopeptide antibiotic Edeine A; [L-Leu1, L-Orn2, D-Phe3, L-Val4, L-Orn5, D-Leu6, L-Ile7, L-Orn8]-Edeine A; NSC 139930
EINECS	Not listed (No EINECS number assigned)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch of Edeine A is verified for identity, purity, and potency using orthogonal methods including HPLC, mass spectrometry, and nuclear magnetic resonance (NMR). Testing conforms to applicable guidelines for research-grade biochemicals, including ACS Reagent Grade specifications where relevant.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent oxidation and moisture uptake. Due to its hygroscopic nature, minimize exposure to ambient humidity during handling. Keep away from strong acids, organic solvents, fluorides, and strong alkalis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identity (HPLC Retention Time)	Matches reference standard (±0.2 min)
Identity (Mass Spectrometry)	[M+H]+ m/z 1323.5 ± 0.3
Assay (HPLC, Area %)	≥ 95.0%
Related Substances (HPLC)	Single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (Karl Fischer)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Microbial Contamination	No detectable bacteria, yeast, or mold (103 CFU/g)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.