Description

16,17-Dihydrorifamycin S is a key semi-synthetic intermediate in the production of advanced rifamycin antibiotics. This compound is critical for pharmaceutical R&D and manufacturing, offering a versatile building block for creating potent antimicrobial agents. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing novel anti-tuberculosis and antibacterial therapies.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of rifamycin derivatives, including rifampicin and rifabutin.
• Antibiotic Research & Development: Serves as a core scaffold for developing new antimicrobial agents targeting resistant bacterial strains.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled production of finished antibiotic drug substances.
• Biochemical Research: Employed in studies investigating the mechanism of action of ansamycin antibiotics against bacterial RNA polymerase.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for HPLC and spectroscopic methods.

Basic Information

Product Name	16,17-Dihydrorifamycin S
CAS No.	51874-02-3
Molecular Formula	C37H47NO12
Molecular Weight	697.77 g/mol
Synonyms	16,17-Dihydro-17-deoxorifamycin S; 16,17-Dihydro-17-deoxy-25-desacetylrifamycin S; Rifamycin SV Intermediate; 16,17-Dihydro-17-deoxy-25-O-desacetylrifamycin S; 16,17-Dihydrorifamycin; 17-Deoxy-16,17-dihydrorifamycin S; 16,17-Dihydro-17-deoxorifamycin S; 16,17-Dihydro-17-deoxy-25-desacetyl-rifamycin S
EINECS	Contact for details

Quality Control

Our 16,17-Dihydrorifamycin S is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Reddish-brown to orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.