Description

Polydeoxyinosinic-Polydeoxy-(5-Bromocytidylic)Acid is a synthetic, double-stranded polynucleotide complex, widely utilized as a potent inducer of interferon and a model compound for nucleic acid research. Its significance lies in its ability to mimic viral double-stranded RNA, making it a critical tool for studying immune response pathways and antiviral mechanisms. This product is essential for researchers and manufacturers in the fields of immunology, virology, and pharmaceutical development, particularly for investigating innate immunity and developing novel therapeutic agents.

Application

• Immunological Research: As a standard inducer of interferon (IFN) for studying the innate immune response and antiviral states in cell cultures and animal models.
• Virology Studies: Used to investigate host-cell defense mechanisms against viral infections and to screen for antiviral compounds.
• Pharmaceutical Development: Serves as a reference standard and active component in the research and development of immunomodulatory and antiviral drugs.
• Molecular Biology: Employed as a model for double-stranded nucleic acid interactions, protein binding studies, and nucleic acid chemistry research.
• Diagnostic Reagent Manufacturing: Potential use in the formulation of reagents for diagnostic assays targeting interferon-related pathways.
• Cell Signaling Research: Applied to activate pattern recognition receptors (PRRs) like TLR3 and RIG-I, facilitating studies in cellular signaling cascades.

Basic Information

Product Name	Polydeoxyinosinic-Polydeoxy-(5-Bromocytidylic)Acid
CAS No.	51853-68-0
Molecular Formula	(C10H11BrN4O7P)n • (C10H12N4O7P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(dI-dC); Poly(deoxyinosinic-deoxycytidylic) acid, brominated; Poly(dI-dC)•Br; Poly(dI)-Poly(Br5dC); Poly(deoxyinosinic acid)-poly(5-bromodeoxycytidylic acid) complex; Poly I:Poly C (brominated analog); 5-Bromo-dC homopolymer complex; dI-dC(Br) copolymer
EINECS	Contact for details

Quality Control

Our Polydeoxyinosinic-Polydeoxy-(5-Bromocytidylic)Acid is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. We provide a detailed Certificate of Analysis (COA) with key parameters including UV absorbance profile, base composition, and endotoxin levels, meeting the rigorous standards required for life science research. Specifications can be tailored to support GMP-grade applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or lyophilized powder
Identification (UV)	Characteristic absorbance profile consistent with structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95% (Polymer content)
Base Ratio (dI:dC[Br])	~1:1 (by HPLC or enzymatic digestion)
Bromine Content	Consistent with theoretical value
Endotoxin	< 10 EU/mg (for cell culture grade)
Solubility	Soluble in aqueous buffers (e.g., TE buffer, saline)
Biological Activity	Induces interferon production in standard bioassay (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.