Description

(R)-(3-Trifluoromethyl)Mandelic Acid is a high-value chiral building block and resolving agent of significant importance in asymmetric synthesis. Its core value lies in the trifluoromethyl group, which imparts unique electronic and steric properties critical for modulating the biological activity and metabolic stability of target molecules. This compound is essential for research and production chemists in the pharmaceutical and agrochemical industries who require enantiomerically pure intermediates for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Chiral Resolving Agent: Used for the optical resolution of racemic mixtures of amines, amino alcohols, and other basic compounds due to its ability to form diastereomeric salts.
• Agrochemical Synthesis: Serves as a building block for advanced herbicides and fungicides where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis, including hydrogenation and carbon-carbon bond-forming reactions.
• Material Science Research: Investigated for the synthesis of specialty polymers and liquid crystals with tailored optical and electronic properties.
• Diagnostic Reagent Manufacturing: Used in the production of chiral selectors for analytical chromatography columns and other diagnostic tools.

Basic Information

Product Name	(R)-(3-Trifluoromethyl)Mandelic Acid
CAS No.	51359-73-0
Molecular Formula	C9H7F3O3
Molecular Weight	220.14 g/mol
Synonyms	(R)-α-Hydroxy-3-(trifluoromethyl)benzeneacetic Acid; (R)-2-Hydroxy-2-[3-(trifluoromethyl)phenyl]acetic Acid; (R)-3-(Trifluoromethyl)mandelic Acid; (R)-OFTMA; (R)-(-)-3-Trifluoromethylmandelic Acid; D-3-Trifluoromethylmandelic Acid; (R)-TFMHA
EINECS	Contact for details

Quality Control

Our (R)-(3-Trifluoromethyl)Mandelic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Production adheres to cGMP guidelines where applicable, supporting its use in advanced research and regulated pre-clinical development. Certificates of Analysis (COA) are provided with each shipment, detailing critical parameters such as chiral purity (HPLC), chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.