Description

2-[(7-Nitro-2,1,3-Benzoxadiazol-4-Yl)Amino]Ethanethiol is a specialized heterocyclic organic compound featuring a benzoxadiazole core functionalized with a nitro group and a thiol-terminated aminoethyl side chain. This unique structure makes it a valuable reagent for the selective derivatization and fluorescent labeling of target molecules, particularly in analytical chemistry. It is primarily sought by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing sensitive detection assays and advanced chemical probes.

Application

• Fluorescent Labeling Reagent: Used for tagging biomolecules such as peptides, proteins, and nucleic acids for detection and analysis via fluorescence spectroscopy or microscopy.
• Analytical Chemistry Standard: Serves as a critical reference standard and derivatization agent in High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS) for quantifying thiol-containing compounds.
• Bioconjugation Chemistry: The reactive thiol group enables site-specific conjugation to maleimide or iodoacetyl-functionalized molecules, useful in creating antibody-drug conjugates (ADCs) or diagnostic kits.
• Sensor Development: Employed in the synthesis of chemosensors and probes designed to detect specific metal ions or biological analytes due to its fluorogenic properties.
• Pharmaceutical Research: Utilized in drug discovery and development for studying drug metabolism, protein interactions, and cellular uptake mechanisms.
• Material Science: Can be incorporated into polymeric materials or surfaces to introduce fluorescent markers for tracking and imaging applications.

Basic Information

Product Name	2-[(7-Nitro-2,1,3-Benzoxadiazol-4-Yl)Amino]Ethanethiol
CAS No.	50540-16-4
Molecular Formula	C8H8N4O3S
Molecular Weight	240.24 g/mol
Synonyms	NBD-SH; 7-Nitro-2,1,3-benzoxadiazole-4-yl-aminoethanethiol; 4-(2-Mercaptoethylamino)-7-nitro-2,1,3-benzoxadiazole; 4-(2-Thioethylamino)-7-nitrobenzofurazan; 2-[(7-Nitro-4-benzofurazanyl)amino]ethanethiol; 4-(2-Mercaptoethylamino)-7-nitrobenzofurazan; NBD ethylenediamine thiol; NBD-AE-SH
EINECS	Contact for details

Quality Control

Our 2-[(7-Nitro-2,1,3-Benzoxadiazol-4-Yl)Amino]Ethanethiol is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each lot undergoes comprehensive analysis, including purity assay and impurity profiling. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its properties of being easily oxidized (store under inert atmosphere) and light-sensitive, prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.