Description

(5)N,(8)n-Deaza-(10)-n-Methylfolate is a chemically modified folate analog designed for enhanced stability and specific biochemical interactions. This compound is critical for research and development in advanced pharmaceutical synthesis and as a key intermediate for novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies focused on metabolic pathway studies, oncology research, and the development of next-generation antifolate drugs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel antifolate chemotherapeutic agents.
• Biochemical Research: Used as a stable analog in studies of folate-dependent enzymatic pathways and one-carbon metabolism.
• Reference Standard: Employed as a high-purity standard in analytical method development and quality control for related APIs.
• Enzyme Inhibition Studies: Investigated for its potential to selectively inhibit specific dihydrofolate reductase (DHFR) variants.
• Precursor for Labeled Compounds: Acts as a precursor for the synthesis of isotopically labeled (e.g., deuterated, C13) folates for tracer studies.
• Nutraceutical R&D: Explored in the development of advanced, stabilized folate forms for specialized nutritional applications.

Basic Information

Product Name	(5)N,(8)n-Deaza-(10)-n-Methylfolate
CAS No.	5854-12-6
Molecular Formula	C₂₀H₂₃N₇O₆
Molecular Weight	457.45 g/mol
Synonyms	N5,N8-Dideaza-N10-methylfolate; 5,8-Dideaza-10-methylfolic acid; 10-Methyl-5,8-dideazafolic acid; (5,8)-Dideaza-10-methylfolate; NSC 154131; 10-Methyl-5,8-dideazapteroylglutamate; 5,8-Dideaza-10-methylpteroyl-L-glutamic acid
EINECS	Contact for details

Quality Control

Our (5)N,(8)n-Deaza-(10)-n-Methylfolate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.