Description

Girard's Reagent D is a specialized hydrazine derivative, chemically known as (Carboxymethyl)trimethylammonium chloride hydrazide, widely recognized for its role as a carbonyl-trapping agent. Its primary value lies in its ability to form stable, water-soluble hydrazone derivatives with aldehydes and ketones, facilitating their isolation and purification from complex mixtures. This makes it an indispensable tool for researchers and manufacturers in pharmaceutical development, analytical chemistry, and organic synthesis, particularly for the purification of steroids and other bioactive molecules.

Application

• Pharmaceutical Intermediate Purification: Selective isolation of ketosteroids and other carbonyl-containing drug intermediates during synthesis.
• Analytical Chemistry: Derivatization agent for the HPLC or GC analysis of aldehydes and ketones to improve detection and separation.
• Organic Synthesis: Protecting group for carbonyl functionalities in multi-step synthetic pathways.
• Biochemistry Research: Tool for studying carbonyl metabolites and trapping reactive carbonyl species in biological systems.
• Flavor and Fragrance Industry: Used in the analysis and purification of carbonyl compounds that are key aroma constituents.
• Quality Control Labs: Employed in reference standard preparation and impurity profiling of APIs (Active Pharmaceutical Ingredients).

Basic Information

Product Name	Girard's Reagent D
CAS No.	5787-71-3
Molecular Formula	C6H16ClN3O2
Molecular Weight	197.66 g/mol
Synonyms	(Carboxymethyl)trimethylammonium chloride hydrazide; Girard-D Reagent; Girard's D Reagent; Trimethylammonioacetohydrazide chloride; 1-Carboxymethyl-1-trimethylammonium chloride hydrazide; Acetic acid hydrazide, 2-(trimethylammonio)-, chloride; [2-(Hydrazinecarbonyl)ethyl]trimethylammonium chloride
EINECS	227-311-4

Quality Control

Our Girard's Reagent D is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, IR for identification, and loss on drying to confirm specification compliance. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.