Description

6α-[[[3-[(Carboxymethyl)Thio]-2-Hydroxypropyl]Thio]Acetyl]Penicillanic Acid is a key semi-synthetic penicillin derivative and a crucial intermediate in the synthesis of advanced β-lactam antibiotics. Its value lies in providing a versatile chemical scaffold for developing potent antimicrobial agents with enhanced stability and efficacy. This compound is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation penicillin-based therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of broad-spectrum penicillin and cephalosporin antibiotics.
• Antibiotic Research & Development: Used in medicinal chemistry for the design and creation of novel β-lactam compounds with improved pharmacological profiles.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in multi-step synthetic routes for producing final antibiotic drug substances.
• Biochemical Research: Utilized in studies investigating the structure-activity relationships (SAR) of β-lactamase inhibitors and penicillin-binding proteins.
• Process Chemistry: Applied in the scale-up and optimization of manufacturing processes for antibiotic APIs under GMP conditions.

Basic Information

Product Name	6α-[[[3-[(Carboxymethyl)Thio]-2-Hydroxypropyl]Thio]Acetyl]Penicillanic Acid
CAS No.	5676-15-3
Molecular Formula	C16H22N2O7S3
Molecular Weight	450.55 g/mol
Synonyms	6-[[[3-[(Carboxymethyl)thio]-2-hydroxypropyl]thio]acetyl]penicillanic acid; (2S,5R,6R)-6-[[[3-[(Carboxymethyl)thio]-2-hydroxypropyl]thio]acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-APA derivative with thioglycolic acid side chain; Penicillin G derivative intermediate; Antibiotic intermediate 5676-15-3
EINECS	Contact for details

Quality Control

Our 6α-[[[3-[(Carboxymethyl)Thio]-2-Hydroxypropyl]Thio]Acetyl]Penicillanic Acid is produced and tested to meet stringent standards suitable for pharmaceutical intermediate applications. Quality is assured through rigorous analytical controls including HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to ensure traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.