Description

Methalthiazide is a high-purity, specialized pharmaceutical intermediate and research chemical. This compound is of significant value for its role in the synthesis and development of diuretic and antihypertensive agents. It is primarily required by pharmaceutical R&D laboratories, API manufacturers, and academic research institutions engaged in cardiovascular drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for diuretic medications.
• Research & Development: Used in pharmacological studies to investigate structure-activity relationships (SAR) within the thiazide diuretic class.
• Reference Standard: Serves as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale manufacturing of related therapeutic compounds.
• Academic Research: Utilized in university and institutional research projects focused on renal physiology and hypertension.

Basic Information

Product Name	Methalthiazide
CAS No.	5611-64-3
Molecular Formula	C₁₀H₁₄ClN₃O₄S₂
Molecular Weight	363.82 g/mol
Synonyms	6-Chloro-3,4-dihydro-3-(methoxymethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Methalthiazide; Methylclothiazide (common variant name); 3-(Methoxymethyl)-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Enduron (associated trade name); 6-Chloro-3-(methoxymethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Benzothiadiazine derivative; Diuretic intermediate
EINECS	227-025-8

Quality Control

Our Methalthiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other validated methods, to ensure it meets stringent specifications for research and pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.