Description

Althiazide is a potent thiazide-like diuretic agent belonging to the benzothiadiazine class of pharmaceuticals. Its primary value lies in its ability to inhibit sodium reabsorption in the distal convoluted tubule of the kidney, making it a critical active pharmaceutical ingredient (API) for managing hypertension and edema. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing antihypertensive and diuretic medications. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final drug product.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of prescription diuretic and antihypertensive medications.
• Hypertension Treatment: Key component in fixed-dose combination drugs or standalone therapies for managing high blood pressure.
• Edema Management: Used in medications to reduce fluid retention associated with conditions like congestive heart failure, liver cirrhosis, and renal dysfunction.
• Research & Development: Serves as a reference standard and building block in pharmacological studies and the development of novel cardiovascular agents.
• Generic Drug Manufacturing: Critical for producers of generic pharmaceutical formulations containing althiazide.
• Clinical Trial Materials: Supplied as a high-purity compound for use in clinical research and bioequivalence studies.

Basic Information

Product Name	Althiazide
CAS No.	5588-16-9
Molecular Formula	C11H14ClN3O4S3
Molecular Weight	383.89 g/mol
Synonyms	6-Chloro-3,4-dihydro-3-[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Altizide; Althiazidum; Altizida; Altizidum; Flumethiazide (related compound); Benzothiadiazine derivative.
EINECS	226-989-5

Quality Control

Our Althiazide is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and IR spectroscopy. We provide full traceability and support regulatory submissions with comprehensive documentation. A detailed Certificate of Analysis (COA) is supplied with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Follow standard pharmaceutical API handling and storage protocols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.