Description

5-Hydroxymethyldeoxyuridylate is a modified nucleotide monophosphate of significant interest in biochemical and pharmaceutical research. This compound serves as a crucial intermediate and reference standard in the study of nucleotide metabolism, DNA synthesis, and the mechanism of action of certain antiviral and anticancer agents. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in the development of nucleoside-based therapeutics and molecular biology reagents.

Application

• Biochemical Research: Used as a key intermediate and reference standard in studies of thymidylate synthase inhibition and nucleotide metabolism pathways.
• Pharmaceutical Development: Serves as a critical building block and impurity standard in the synthesis and quality control of novel antiviral and anticancer nucleoside analogs.
• Diagnostic Reagent Manufacturing: Employed in the formulation of enzyme substrates and kits for diagnostic assays targeting DNA synthesis enzymes.
• Academic Research: Utilized in molecular biology and enzymology laboratories to investigate DNA replication, repair mechanisms, and enzyme kinetics.
• Life Science Tools: Incorporated into specialized reagents and buffers for high-throughput screening and target validation in drug discovery.

Basic Information

Product Name	5-Hydroxymethyldeoxyuridylate
CAS No.	5238-86-8
Molecular Formula	C11H15N2O9P
Molecular Weight	350.22 g/mol
Synonyms	5-Hydroxymethyl-2'-deoxyuridine 5'-monophosphate; 5-Hydroxymethyldeoxyuridine monophosphate; 5-HMdUMP; 5-(Hydroxymethyl)-2'-deoxyuridylic acid; dUMP-5-CH2OH; 5-Hydroxymethyl-dUMP; 2'-Deoxy-5-(hydroxymethyl)uridylic acid
EINECS	Contact for details

Quality Control

Our 5-Hydroxymethyldeoxyuridylate is produced under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support regulatory and research documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.