Description

2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzoic Acid is a highly fluorinated benzoic acid derivative, valued for its unique combination of strong electron-withdrawing properties and steric bulk. This compound serves as a critical building block in advanced organic synthesis, particularly for introducing perfluoroalkyl aromatic motifs. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require high-purity intermediates to develop novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system and anti-inflammatory pathways.
• Agrochemical Synthesis: Used to create advanced herbicides and pesticides, where the fluorine atoms enhance biological activity, stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing components in electronic display materials, improving thermal stability and optical properties.
• Polymer Modification: Incorporated into specialty polymers to impart chemical resistance, low surface energy, and improved durability for coatings and high-performance plastics.
• Organic Synthesis Reagent: Employed as a versatile reagent in coupling reactions and for the preparation of complex fluorinated aromatic compounds in R&D.

Basic Information

Product Name	2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzoic Acid
CAS No.	5216-22-8
Molecular Formula	C8HF7O2
Molecular Weight	250.08 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzoic Acid; 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzoic Acid; Perfluoromethylbenzoic Acid (derivative); TFTBA; Benzoic acid, 2,3,5,6-tetrafluoro-4-(trifluoromethyl)-; α,α,α,2,3,5,6-Heptafluorotoluic Acid
EINECS	226-025-8

Quality Control

Our production of 2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality system is designed to support applications requiring high-purity intermediates under cGMP and ISO 9001 frameworks where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.