Description

Nafiverine CAS NO 5061-22-3 is a pharmaceutical intermediate and active compound of significant interest in medicinal chemistry. Its primary value lies in its role as a key building block for the synthesis of more complex therapeutic agents, particularly in research and development settings. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on developing new drug candidates or producing specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of target drug molecules, particularly in central nervous system (CNS) or cardiovascular research.
• Active Pharmaceutical Ingredient (API) Development: Used as a starting material or an intermediate in the development and scale-up of new APIs.
• Medicinal Chemistry Research: Employed in academic and industrial R&D for structure-activity relationship (SAR) studies and the creation of novel chemical libraries.
• Fine Chemical Synthesis: Acts as a specialized reagent for constructing complex organic molecules requiring its specific molecular framework.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Reference Standard: Can be supplied in high-purity grades for use as an analytical standard in quality control laboratories.

Basic Information

Product Name	Nafiverine
CAS No.	5061-22-3
Molecular Formula	C20H21NO3
Molecular Weight	323.39 g/mol
Synonyms	Nafiverine; 1-(3,4-Dimethoxyphenyl)-5,6-dimethoxy-3-methylisoquinoline; 5,6,7,8-Tetrahydro-6-(3,4,5-trimethoxyphenyl)isoquinoline; Nafiverin; 1-(3,4-Dimethoxyphenyl)-5,6-dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline; 6-(3,4,5-Trimethoxyphenyl)-5,6,7,8-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our Nafiverine is produced and tested under a strict quality management system to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. For projects requiring regulatory support, we can supply material manufactured under current Good Manufacturing Practice (cGMP) guidelines and compliant with major pharmacopoeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.