Description

4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carbothioic Acid, 6-[3-(o-Chlorophenyl)-5-Methyl-4-Isoxazolecarboxamido]-3,3-Dimethyl-7-Oxo- (7Ci,8Ci) is a high-purity, advanced pharmaceutical intermediate with the CAS number 5053-36-1. This compound is a critical building block in the synthesis of specific β-lactam antibiotics, offering researchers and manufacturers a reliable starting material for complex molecular construction. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) producers engaged in the development and scale-up of novel antimicrobial agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthetic pathway for specialized β-lactam antibiotic candidates.
• Antimicrobial Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in the discovery of new antibacterial agents.
• API Synthesis: Used in the pilot-scale and commercial production of specific, complex antibiotic active pharmaceutical ingredients.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic & Contract Research: Utilized in university and CRO settings for advanced organic synthesis and medicinal chemistry projects.

Basic Information

Product Name	4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carbothioic Acid, 6-[3-(o-Chlorophenyl)-5-Methyl-4-Isoxazolecarboxamido]-3,3-Dimethyl-7-Oxo- (7Ci,8Ci)
CAS No.	5053-36-1
Molecular Formula	C19H20ClN3O4S2
Molecular Weight	453.96 g/mol
Synonyms	6-[(3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carbothioic acid; (2S,5R,6R)-6-[[(3-(2-Chlorophenyl)-5-methylisoxazol-4-yl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carbothioic Acid; Cloxacillin Related Compound A (EP Impurity A); Cloxacillin EP Impurity A; Cloxacillin Impurity A; 5-Methyl-3-o-chlorophenylisoxazole-4-carboxamidopenicillanic Acid; Penicillanic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation and residual solvent analysis, to ensure it meets exacting specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with relevant pharmacopeial guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.