Description

Ethyl 4-(Trifluoromethyl)Benzoate is a high-value fluorinated aromatic ester, serving as a critical synthetic intermediate in advanced chemical manufacturing. Its molecular structure, featuring a benzoate ester linked to a trifluoromethyl group, provides unique electronic and steric properties essential for modifying compound characteristics. This product is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecules where the introduction of fluorine is required.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a trifluoromethylphenyl moiety to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to improved efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific properties such as chemical resistance, thermal stability, or altered surface energy.
• Organic Synthesis Reagent: A versatile reagent in cross-coupling reactions, esterifications, and other transformations for introducing the 4-(trifluoromethyl)benzoyl group into target molecules.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments that offer unique color fastness and spectral properties.

Basic Information

Product Name	Ethyl 4-(Trifluoromethyl)Benzoate
CAS No.	583-02-8
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	Ethyl p-(Trifluoromethyl)benzoate; 4-(Trifluoromethyl)benzoic Acid Ethyl Ester; Benzoic acid, 4-(trifluoromethyl)-, ethyl ester; Ethyl α,α,α-Trifluoro-p-toluate; p-Trifluoromethylbenzoic Acid Ethyl Ester; Ethyl 4-(Trifluoromethyl)benzenecarboxylate; NSC 406925
EINECS	209-503-6

Quality Control

Our Ethyl 4-(Trifluoromethyl)Benzoate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chromatography and spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting key parameters such as assay and impurity profiles. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.