Description

7-Methylguanine is a modified purine nucleobase of significant interest in biochemical and pharmaceutical research. This compound serves as a critical reference standard and building block for studying DNA alkylation damage, repair mechanisms, and epigenetic modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, toxicology, and molecular biology. The high-purity material is essential for accurate analytical calibration and the synthesis of specialized nucleotides.

Application

• Biochemical Research Standard: Used as a certified reference material (CRM) for the quantification and study of DNA adducts and methylation events.
• Pharmaceutical Development: Acts as a key intermediate in the synthesis of novel nucleoside analogs for potential antiviral or anticancer therapeutics.
• Toxicology Studies: Employed to investigate the mechanisms and biomarkers of exposure to alkylating agents and environmental toxins.
• Diagnostic Reagent Manufacturing: Incorporated into kits and assays designed to detect specific DNA modifications or repair enzyme activity.
• Epigenetics Research: Utilized in studies focusing on the role of base modifications in gene expression and regulation.
• Academic Research: Serves as a fundamental reagent in university laboratories for teaching and advanced research in nucleic acid chemistry.

Basic Information

Item	Detail
Product Name	7-Methylguanine
CAS No.	578-76-7
Molecular Formula	C6H7N5O
Molecular Weight	165.15 g/mol
Synonyms	7-Methylguanine; 2-Amino-7-methyl-1,7-dihydro-6H-purin-6-one; 2-Amino-7-methyl-6H-purin-6-one; 7-Methyl-2-aminopurine-6(1H)-one; 7-Methylguanine (base); N7-Methylguanine; Guanine, 7-methyl-; 6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-
EINECS	209-438-6

Quality Control

Our 7-Methylguanine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom purity grades, including >98% and >99%, are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0 %
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.