Description

Penicillin X is a biosynthetic penicillin antibiotic, also known as p-Hydroxybenzylpenicillin, with the CAS registry number 525-91-7. This compound serves as a crucial intermediate and reference standard in pharmaceutical research and development, particularly for studying penicillin structure-activity relationships and degradation pathways. It is essential for manufacturers and R&D laboratories in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity antibiotic intermediates for synthesis, analytical testing, and quality control.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of specialized penicillin derivatives and related β-lactam antibiotics.
• Analytical Reference Standard: Used as a certified reference material (CRM) in HPLC, LC-MS, and other chromatographic methods for quality assurance and regulatory testing of antibiotic products.
• Microbiological Research: Employed in studies investigating antibiotic resistance mechanisms, bacterial cell wall synthesis inhibition, and the spectrum of activity of penicillin variants.
• Biochemical Studies: Utilized as a substrate or inhibitor in enzymatic assays to study penicillin-binding proteins (PBPs) and β-lactamase activity.
• Fine Chemical Synthesis: Serves as a building block for the preparation of more complex molecules in medicinal chemistry and drug discovery programs.
• Quality Control Laboratories: Essential for pharmaceutical QC labs to perform identity, purity, and potency tests, ensuring batch-to-batch consistency and compliance with pharmacopeial standards (e.g., USP, EP).

Basic Information

Product Name	Penicillin X
CAS No.	525-91-7
Molecular Formula	C16H18N2O5S
Molecular Weight	350.39 g/mol
Synonyms	p-Hydroxybenzylpenicillin; 4-Hydroxybenzylpenicillin; Penicillin III; FEMA 4618; Benzylpenicillin, 4-hydroxy-; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(4-hydroxyphenyl)acetamido]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
EINECS	208-380-3

Quality Control

Our Penicillin X is produced and tested under strict quality management systems. Each batch undergoes comprehensive analysis to ensure it meets high-purity standards suitable for research and pharmaceutical applications. We provide Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, with testing performed according to validated methods. The product can be supplied to meet various pharmacopeial specifications (USP, EP) upon request, ensuring reliability and traceability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Specific Rotation	+280° to +310° (c=1 in water)
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.