Description

Apomorphine is a potent, non-narcotic dopamine receptor agonist with significant pharmacological activity. This compound is critical for research and development in advanced neurological therapeutics, particularly for managing motor fluctuations in Parkinson's disease. It is essential for pharmaceutical manufacturers, research institutions, and fine chemical suppliers focused on central nervous system (CNS) drug development and synthesis.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of injectable treatments for "off" episodes in Parkinson's disease.
• Neurological Research: A key reference standard and tool compound for studying dopamine D1 and D2 receptor pathways and mechanisms of emesis.
• Chemical Synthesis: Serves as a sophisticated intermediate or starting material for the synthesis of novel dopaminergic analogs and derivatives.
• Analytical Standard: Used as a high-purity calibrant in HPLC, LC-MS, and other analytical methods for quality control and pharmacokinetic studies.
• Preclinical Development: Employed in animal models to investigate treatments for addiction (e.g., opioid and alcohol dependence) and other CNS disorders.

Basic Information

Product Name	Apomorphine
CAS No.	58-00-4
Molecular Formula	C17H17NO2
Molecular Weight	267.32 g/mol
Synonyms	(6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol; (R)-(-)-Apomorphine; (-)-Apomorphine; R-(-)-Apomorphine; Apomorphine Hydrochloride (salt form); 6aβ-Aporphine-10,11-diol; Uprima (brand name); APO
EINECS	200-360-1

Quality Control

Our Apomorphine is manufactured under strict quality management systems. It is typically supplied to meet high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) are provided with each batch, detailing parameters such as assay, enantiomeric purity, and related substances. We support compliance with cGMP, ICH Q7, and relevant pharmacopoeial guidelines (e.g., USP, EP) for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to prevent oxidation.

Specification

Item	Specification
Appearance	White to grayish-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Enantiomeric Purity	≥99.0% (R-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.