Description

Radiprodil is a selective and potent antagonist of the NR2B subunit of the NMDA receptor, representing a significant compound for neurological research. Its mechanism of action makes it a valuable tool for investigating pathways related to pain, neurodegenerative diseases, and neuroprotection. This high-purity compound is essential for pharmaceutical R&D, academic research, and the development of novel central nervous system (CNS) therapeutics.

Application

• Neurological Research: A critical tool for studying the role of NMDA receptors, particularly the NR2B subunit, in synaptic plasticity, learning, and memory.
• Pain Pathway Investigation: Used in preclinical research to explore mechanisms of neuropathic and chronic pain, aiding in the development of new analgesic candidates.
• Neurodegenerative Disease Models: Applied in research models for conditions such as Parkinson's disease, Alzheimer's disease, and Huntington's disease to understand excitotoxicity and neuronal cell death.
• Neuroprotection Studies: Employed to investigate compounds and mechanisms that may protect neurons from ischemic stroke or traumatic brain injury.
• Psychiatric Disorder Research: Useful in studying the glutamatergic system's involvement in depression, anxiety, and schizophrenia.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in drug discovery and development pipelines.

Basic Information

Product Name	Radiprodil
CAS No.	496054-87-6
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	RGH-896; (R)-(+)-4-[2-(4-Fluorophenyl)-2-oxo-1-(phenylmethyl)ethyl]-1-piperazinecarboxylic Acid Methyl Ester; (R)-4-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-1-piperazinecarboxylic Acid Methyl Ester; (R)-Methyl 4-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)piperazine-1-carboxylate; NR2B Antagonist RGH-896; Radiprodil (RGH-896)
EINECS	Contact for details

Quality Control

Our Radiprodil is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.