Description

4-(2-Chloro-4-Fluorophenyl)Benzoic Acid is a high-purity, halogenated aromatic carboxylic acid building block of significant importance in advanced organic synthesis. Its unique molecular structure, featuring both chloro and fluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the halogenated biphenyl core contributes to bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing advanced functional materials, including liquid crystal compounds and organic light-emitting diode (OLED) materials, due to its rigid, halogenated aromatic structure.
• Polymer Modifier: Employed to introduce halogenated aromatic units into polymer backbones, enhancing properties such as thermal stability, flame retardancy, and chemical resistance.
• Chemical Research & Development: A versatile scaffold in medicinal chemistry and material science for structure-activity relationship (SAR) studies and the creation of novel chemical libraries.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-batch clinical trial materials.

Basic Information

Product Name	4-(2-Chloro-4-Fluorophenyl)Benzoic Acid
CAS No.	479079-33-9
Molecular Formula	C13H8ClFO2
Molecular Weight	250.65 g/mol
Synonyms	[2-Chloro-4-fluorophenyl]-4-benzoic acid; 4-(2-Chloro-4-fluorophenyl)benzoic acid; 2'-Chloro-4'-fluorobiphenyl-4-carboxylic acid; 4-Carboxy-2'-chloro-4'-fluorobiphenyl; Biphenyl-4-carboxylic acid, 2-chloro-4'-fluoro-; (2-Chloro-4-fluorophenyl)benzoic acid; 4-(2-Chloro-4-fluorophenyl)benzoic acid CAS 479079-33-9
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-4-Fluorophenyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.