Description

T-Butyl 4-Formyl-3,5-Difluorobenzoate is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms and formyl groups is critical for modulating biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated drug candidates, especially in kinase inhibitors, anti-cancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where the difluoro and formyl functionalities enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials for improved performance characteristics.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom chemical synthesis services catering to the fine chemical and life science industries.

Basic Information

Product Name	T-Butyl 4-Formyl-3,5-Difluorobenzoate
CAS No.	467442-12-2
Molecular Formula	C12H12F2O3
Molecular Weight	242.22 g/mol
Synonyms	4-Formyl-3,5-difluorobenzoic acid tert-butyl ester; tert-Butyl 4-formyl-3,5-difluorobenzoate; 3,5-Difluoro-4-formylbenzoic acid tert-butyl ester; Benzoic acid, 4-formyl-3,5-difluoro-, 1,1-dimethylethyl ester; T-Butyl 3,5-difluoro-4-formylbenzoate; 467442-12-2; 4-Carboxy-2,6-difluorobenzaldehyde tert-butyl ester
EINECS	Contact for details

Quality Control

Our T-Butyl 4-Formyl-3,5-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and absorption of moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.