Description

2-(2-Trifluoromethylphenyl)-2-Oxoacetic Acid is a specialized fluorinated organic acid building block of significant interest in advanced chemical synthesis. Its core value lies in the unique reactivity of the oxoacetic acid moiety combined with the electron-withdrawing and lipophilicity-enhancing properties of the trifluoromethyl group. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require high-purity intermediates for developing novel active ingredients, particularly for creating complex molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a trifluoromethylphenyl-oxoacetic acid fragment.

Basic Information

Product Name	2-(2-Trifluoromethylphenyl)-2-Oxoacetic Acid
CAS No.	467435-08-1
Molecular Formula	C9H5F3O3
Molecular Weight	218.13 g/mol
Synonyms	2-Oxo-2-[2-(trifluoromethyl)phenyl]acetic Acid; α-Oxo-2-(trifluoromethyl)benzeneacetic Acid; 2-(2-Trifluoromethylbenzoyl)formic Acid; (2-Trifluoromethylphenyl)oxoacetic Acid; 2-Trifluoromethylphenylglyoxylic Acid; 2-(α,α,α-Trifluoro-o-tolyl)oxoacetic Acid; o-Trifluoromethylphenylglyoxylic Acid; 467435-08-1
EINECS	Contact for details

Quality Control

Our 2-(2-Trifluoromethylphenyl)-2-Oxoacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, and incompatible materials such as strong bases and oxidizing agents. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.