Description

Ethyl 4-Bromo-3-(Trifluoromethyl)Benzoate is a high-value, multi-functional aromatic ester building block, distinguished by its bromine and trifluoromethyl substituents. This compound is essential for facilitating advanced synthetic transformations, offering chemists a versatile handle for cross-coupling reactions and the introduction of lipophilic, electron-withdrawing groups. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes, enzyme inhibitors, and tags for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences market.

Basic Information

Product Name	Ethyl 4-Bromo-3-(Trifluoromethyl)Benzoate
CAS No.	463355-64-8
Molecular Formula	C10H8BrF3O2
Molecular Weight	297.07 g/mol
Synonyms	Ethyl 4-Bromo-3-(trifluoromethyl)benzoate; Benzoic acid, 4-bromo-3-(trifluoromethyl)-, ethyl ester; 4-Bromo-3-(trifluoromethyl)benzoic acid ethyl ester; Ethyl 4-bromo-α,α,α-trifluoro-m-toluate; 463355-64-8; Ethyl 4-bromo-3-trifluoromethylbenzoate
EINECS	Contact for details

Quality Control

Our Ethyl 4-Bromo-3-(Trifluoromethyl)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.