Description

Fluorocholine CAS NO 459424-38-5 is a specialized fluorinated analog of choline, a vital biochemical precursor. This compound is of significant interest in the fields of medical imaging and biochemical research, particularly for its role in positron emission tomography (PET) tracer synthesis. It serves as a critical building block for researchers and pharmaceutical developers working in oncology and neurology. Its unique structure enables the study of cellular metabolism and membrane phospholipid synthesis in vivo.

Application

• PET Tracer Precursor: Primary use as a key intermediate in the synthesis of Fluorine-18 labeled choline analogs (e.g., [18F]Fluorocholine) for diagnostic oncology imaging.
• Oncology Research: Used in the development and study of PET imaging agents for detecting and monitoring prostate cancer, brain tumors, and other malignancies with upregulated choline kinase activity.
• Biochemical Probe: Acts as a tool compound in research to investigate choline metabolism, phospholipid biosynthesis, and cell membrane dynamics in various disease models.
• Radiopharmaceutical Synthesis: Essential raw material in GMP-compliant facilities for the production of clinical-grade radiopharmaceuticals.
• Neurological Studies: Applied in research to image brain tumors and study neurological disorders where alterations in choline metabolism are implicated.
• Preclinical Development: Utilized in drug discovery and development pipelines for validating new imaging targets and therapeutic approaches.

Basic Information

Product Name	Fluorocholine
CAS No.	459424-38-5
Molecular Formula	C5H13FNO
Molecular Weight	122.16 g/mol
Synonyms	2-Fluoro-N,N,N-trimethylethanaminium; (2-Fluoroethyl)trimethylammonium; Fluorocholine chloride (common salt form); FCH; [18F]Fluorocholine precursor; N,N,N-Trimethyl-2-fluoroethanaminium; Choline, 2-fluoro-; FLT precursor analog (in context)
EINECS	Contact for details

Quality Control

Our Fluorocholine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and radiopharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for advanced pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements for preclinical or clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.