Description

Vipadenant is a potent and selective antagonist of the adenosine A2A receptor, a key target in neurological research. This high-purity compound is essential for advancing studies in Parkinson's disease and other movement disorders where adenosine signaling plays a critical role. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs engaged in preclinical neuroscience and drug discovery programs.

Application

• Neurological Research: Primary tool compound for investigating the role of adenosine A2A receptors in Parkinson's disease models.
• Drug Discovery: Used as a reference standard and lead compound in the development of novel A2A receptor antagonists for CNS disorders.
• Preclinical Studies: Employed in in vitro binding assays and in vivo behavioral studies to assess efficacy and mechanism of action.
• Biochemical Pathway Analysis: Critical for studying adenosine-mediated signaling cascades and their modulation in neural circuits.
• Academic Research: Supports fundamental neuroscience research into motor control, cognition, and neuroprotection.
• Reference Material: Serves as a high-purity analytical standard for method development and quality control in related API synthesis.

Basic Information

Product Name	Vipadenant
CAS No.	442908-10-3
Molecular Formula	C22H25FN6O2
Molecular Weight	424.48 g/mol
Synonyms	BIIB014; V2006; 2-(Furan-2-yl)-7-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; 7-[2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; Adenosine A2A Receptor Antagonist BIIB014
EINECS	Contact for details

Quality Control

Our Vipadenant is manufactured under strict quality management systems to ensure batch-to-batch consistency for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring material integrity and reliable performance in sensitive assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.