Description

3-(2,2,2-Trifluoro-Ethoxymethyl)-Benzoic Acid is a specialized fluorinated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the benzoic acid core with a trifluoroethoxymethyl side chain, which imparts distinct electronic and steric properties for modifying compound activity and stability. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS, metabolic, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorinated moiety enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal properties.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance, lower surface energy, and improved optical characteristics.
• Organic Ligand Synthesis: Utilized to prepare complexing agents and ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile scaffold for medicinal chemistry, exploring structure-activity relationships (SAR) in drug discovery programs.

Basic Information

Product Name	3-(2,2,2-Trifluoro-Ethoxymethyl)-Benzoic Acid
CAS No.	438475-19-5
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	[3-(2,2,2-Trifluoroethoxymethyl)phenyl]formic acid; Benzoic acid, 3-[(2,2,2-trifluoroethoxy)methyl]-; 3-[(2,2,2-Trifluoroethoxy)methyl]benzoic acid; m-(Trifluoroethoxymethyl)benzoic acid; CAS 438475-19-5; TFEMBA (abbreviation)
EINECS	Contact for details

Quality Control

Our production of 3-(2,2,2-Trifluoro-Ethoxymethyl)-Benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting customer specifications. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.